Parkinson's Disease Department of Neurology The University of Chicago Medical Center Hospitals

 

CLINICAL RESEARCH TRIALS

The University of Chicago Center for Parkinson's Disease and Movement Disorders has active research programs looking at new ways to treat these illnesses.

If you have recently been diagnosed with the following diseases, please contact Joan Young to find out if you can participate in a study that seeks to better understand the origins of these disorders and test new therapies. Please call Joan Young at 773-834-1688 or e-mail her at move@uchicago.edu.

Recently completed studies:

Parkinsonís Research: The Organized Genetics Initiative (PROGENI) Parkinsonís Disease Collaborative Study of Genetic Linkage
This study is looking for brothers and sisters (sibling pairs) affected with Parkinsonís disease or a family history of Parkinsonís disease in a first degree relative. This study has no age restriction, involves one visit, a blood draw for genetic studies and questionnaires.

Identification of Splice Variants as Molecular Markers in Parkinsonís Disease
This study is looking for newly diagnosed subjects with Parkinsonís disease and subjects that are not on any medication for Parkinsonís disease. Study subjects will be between 30 and 85 years old. This study will also use age-matched subjects who do not have Parkinsonís disease as controls. This study requires 1 visit, a blood draw for splice varients as molecular markers and Parkinsonís disease testing.

Effects of Coenzyme Q10 in Parkinsonís Disease Ė Phase III (QE3)
This study will look at the effects of Coenzyme Q10 in slowing the progressive impairment in subjects with Parkinsonís disease. The study will included newly diagnosed subjects with Parkinson Ďs disease that are 30 years old or older and subjects that are not yet taking medications for Parkinsonís disease. This study is aproximately 17 months long.

Laboratory Models of Drug-Induced Gambling
We are testing patients with Parkinsonís disease who are treated with dopamine agonists such as pramipexole and ropinirole. We include those who are experiencing excessive behaviors such as gambling, hypersexuality, and shopping binges as well as those who are not. We are hoping to understand the underlying behavioral traits that are related to dopamine to understand this phenomenon.

Cooperative Huntingtonís Observational Research Trial COHORT
Sponsored by the Huntington's Study Group. This study is an observational research study involving subjects with Huntington's disease and family members of patients with HD. Subjects will be 18 years old or older. The study involves annual visits, and requires the subject to complete a series of questionnaires, cognitive tests and a blood draw for genetic testing.

A Longitudinal Observational Follow-up of the PRECEPT Study Cohort (PostCEPT)
A Parkinsonís disease study that requires annual visits for subjects that have completed The PreCept study.

Dystonia
Prospective, double-blind, placebo-controlled, randomized, multi-center trial with a double-blind parallel-group extension period to investigate the efficacy and safety of different doses of NT 201 in the treatment of cervical dystonia (Mertz) This study is for subjects with Cervical Dystonia.

Deep Brain Stimulation for dystonia (compassionate IND)